Two had clinical signs of septic arthritis the two others had sinus tract. Three had relapsing PKI despite suppressive antibiotics following open DAIR. ![]() All had several previous prosthetic knee revisions without prosthesis loosening. Four patients (79–89 years old) were treated with the LysinDAIR procedure. Exebacase (75 mg/mL 30 mL) was administered directly into the joint during arthroscopy. A written consent was obtained for each patient. Each use was decided in agreement with the French health authority and in accordance with the local ethics committee. epidermidis PKI with no therapeutic option or therapeutic dead end (for whom revision or transfemoral amputation is not feasible and no other oral option is available). In our BJI reference regional center, arthroscopic debridement and implant retention with local administration of exebacase (LysinDAIR) followed by suppressive tedizolid as salvage therapy is proposed for elderly patients with recurrent MDR S. In elderly patients who have undergone several revisions, prosthesis explantation could be associated with definitive loss of function and mortality. epidermidis prosthetic knee infection (PKI), the only surgical option is prosthesis exchange. In patients with relapsing multidrug-resistant (MDR) S. aureus bacteremia and (ii) demonstrated antibiofilm activity in vitro against S.
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